High fiber diets are likely responsible for inhibiting gout related inflammation created by monosodium urate (MSU) crystals. Research shows the high-fiber diets activates microorganisms in the gut to produce short chain fatty acids (SCFA) which induce neutrophil apoptosis at result in the end of inflammation.
The hope is to understand how food interacts with organisms and can improve peoples’ lives whether they are sick or well. In the experiment, scientists used a high-fiber diet and treatment with SCFA and injected MSU crystals into the knees of mice.
They observed the creation of neutrophil apoptosis and efferocytosis and, as the inflammation was resolved, cytokines were produced. Cytokines are anti-inflammatory and, in this case were produced in the knee joints which prevented knee damage and dysfunction. These findings have important implications in treating gout and arthritis.